Batter Jordan Cox and 20-year-old batting all-rounder Jacob Bethell will make their England debuts in the first T20 against Australia on Wednesday in Southampton.
Jamie Overton will also play his first T20 for England, adding to his one Test cap, which came against New Zealand in 2022.
Bowler Saqib Mahmood makes his first England appearance since March 2023 having overcome a second stress fracture in his back.
Three T20s against Australia are followed by five one-day internationals with England picking a youthful squad as they look to the future after relinquishing their T20 and 50-over world titles in the past 10 months.
Marcus Trescothick will act as interim coach throughout the series following the departure of Matthew Mott earlier this summer.
Brendon McCullum has been appointed permanent head coach, combining the white-ball role with his job in charge of the Test side, but does not start the role until the new year.
Phil Salt will captain the side during the T20s in the absence of injured skipper Jos Buttler.
More to follow
Read More: England v Australia: Jordan Cox and Jacob Bethell to make debuts in first T20